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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
20
Human Site:
S649
Identified Species:
31.43
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S649
E
V
I
E
V
D
E
S
D
V
E
E
D
I
F
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S649
E
V
I
E
V
D
E
S
D
V
E
E
D
I
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S649
E
V
I
E
V
D
E
S
D
V
E
E
D
I
F
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S648
E
T
I
E
V
D
D
S
D
E
D
D
I
F
P
Rat
Rattus norvegicus
Q9JIM0
706
80103
S648
E
T
I
E
V
D
E
S
D
D
D
D
S
F
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
I648
T
K
N
Y
S
E
V
I
V
D
D
D
S
D
M
Chicken
Gallus gallus
Q9IAM7
700
80005
D642
F
S
E
D
I
I
D
D
E
M
D
L
E
E
S
Frog
Xenopus laevis
Q9W6K1
711
81112
S646
E
D
I
E
D
D
D
S
D
L
E
E
V
S
F
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
P560
A
M
E
S
D
E
E
P
S
S
A
P
P
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
R559
S
T
A
P
A
T
G
R
G
A
A
R
G
R
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
P656
I
S
R
H
S
K
Q
P
T
T
R
G
R
G
R
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
V457
G
Q
A
V
R
E
Y
V
D
K
E
E
K
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
S647
S
S
S
E
D
D
E
S
T
K
G
K
G
R
K
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
I634
D
I
D
E
N
D
I
I
M
V
S
T
D
E
E
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
E669
D
D
D
E
E
E
E
E
A
D
E
E
E
E
D
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
46.6
53.3
N.A.
0
0
60
6.6
N.A.
0
N.A.
0
20
P-Site Similarity:
100
100
N.A.
100
N.A.
66.6
66.6
N.A.
20
46.6
73.3
26.6
N.A.
0
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
26.6
26.6
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
40
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
14
0
7
0
0
0
7
7
14
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
14
14
7
20
54
20
7
47
20
27
20
27
7
7
% D
% Glu:
40
0
14
60
7
27
47
7
7
7
40
40
14
27
7
% E
% Phe:
7
0
0
0
0
0
0
0
0
0
0
0
0
14
27
% F
% Gly:
7
0
0
0
0
0
7
0
7
0
7
7
14
7
7
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
7
40
0
7
7
7
14
0
0
0
0
7
20
0
% I
% Lys:
0
7
0
0
0
7
0
0
0
14
0
7
7
0
7
% K
% Leu:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
7
7
0
0
0
0
7
% M
% Asn:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
0
0
0
14
0
0
0
7
7
0
14
% P
% Gln:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
7
0
7
0
0
7
0
0
7
7
7
14
14
% R
% Ser:
14
20
7
7
14
0
0
47
7
7
7
0
14
7
7
% S
% Thr:
7
20
0
0
0
7
0
0
14
7
0
7
0
0
0
% T
% Val:
0
20
0
7
34
0
7
7
7
27
0
0
7
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _